1. 1.杮妛尋媶強偼丄杮擭搙乮椷榓係擭搙乯偐傜堛椕宯婇嬈丒僔僲僥僗僩幮偲丄僸僩幘姵偺恌抐偲帯椕朄偺奐敪偵偮偄偰嫟摨尋媶傪峴偆偙偲偱崌堄偟傑偟偨丅

1. 2.嫤榓僉儕儞幮偼丄郌扟惓巎妛挿丒尋媶強挿偲2008擭偵嫟摨尋媶偵傛傝奐敪偟偨儅儖僠僉僫乕僛慾奞嵻乮VEGFR1/FLT1, VEGFR2, VEGFR3慾奞嵻乯偺栻嵻奐敪傪恑傔丄嶐擭乮2021擭乯偵暷崙FDA偐傜恡憻偑傫帯椕偺堛栻昳偲偟偰偺彸擣傪摼傑偟偨丅杮栻嵻偼丄彜昳柤僠儃僓僯僽(tivozanib) 偲偟偰丄暷崙摍偱偑傫偺帯椕偵棙梡偝傟偰偄傑偡乮抦揑嵿嶻尃偼慡偰婇嬈偵懏偟傑偡乯丅暥專丗Taguchi, E., Nakamura K, Miura T, Shibuya M, Isoe T. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci. 99, 623-630, 2008.

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